Single Cell Spatial Proteomics with Filip Karlsson, Pixelgen

Chapters:

0:00 A unique new spatial technology that does not use microscopy

6:05 Why focus on cell surface proteins?

8:00 Applications

17:37 How might this impact patients

A paper out this week in Nature Methods demonstrates a new technology which shows novel patterns of protein spatial polarization and co-localization in immune cells. The technology launched by Swedish startup Pixelgen Technologies has been dubbed “molecular pixelation” because it uses DNA pixels to tag and reveal relative locations. Unlike most other spatial technologies, molecular pixelation does not involve microscopy.

Lead author of the paper, Filip Karlsson who is CTO and co-founder of Pixelgen, joins us today to explain the technology and how it might enable new proteomics research.  He says that immunology is a great application area.

How does this technology fit in the spatial landscape, and how might it enable new medicine that could impact patients?